Dynamical modelling and analysis of biological regulatory networks
9-13 May 2005

CIRM - Centre International de Rencontres Mathématiques
Luminy - Marseille - France

Program

Last update: 29th april 2005

The meeting will include a series of long talks by invited speakers, followed by shorter contributed talks, yet keeping ample time for discussion.

Monday, May 9th

• 10:30 Welcoming session
• 11:00 Introduction (Denis Thieffry)
• Session: "Genetic networks and embryonic development".
  • 11:30-12:30 Hans Meinhardt (MPIE, Tubingen, Allemagne): Models for axes formation in higher organisms.
  • Lunch
  • 14:00-14:45 Lucas Sánchez (CIB, Madrid, Espagne): A formal analysis of the segmentation process in Drosophila.
  • 14:45-15:30 John Reinitz (SUNY, New York, USA): Regulation and Variation in Drosophila Segment Determination.
  • Break
  • 16:00-16:45 Andrea Ciliberto (FIRC, Milan, Italie) : Oscillations and steady states in the p53/Mdm2 molecular network.
  • 16:45-17:30 Marcelline Kaufman (CeNoLi, Bruxelles, Belgique): Link between logical structure and dynamical behavior: the example of the p53-mdm2 network.

• Session: "Dynamical modelling and analysis: mathematical and methodological frameworks".
  • 9:30-10:30 René Thomas (CeNoLi, Bruxelles, Belgique): Frontier diagrams: partition of phase space according to the signs of the eigenvalues or to the signs patterns of the circuits.
  • Break
  • 11:00-11:45 Christophe Soulé (CNRS et IHES) : A new necessary condition for multistationarity.
  • 11:45-12:30 Jean-Luc Gouzé (INRIA, Sophia Antipolis): Piecewise-linear Models of Genetic Regulatory Networks: Equilibria and their Stability
  • Lunch
  • 15:00-16:00 Leon Glass (McGill, Montreal, Canada): The Inverse Problem for Genetic Networks.
  • Break
  • 16:30-17:00 Fabien Corblin (IMAG, Grenoble) : Modélisation, inférence et simulation de réseaux logiques multivalués asynchrones à l'aide de la Programmation Logique avec Contraintes (PLC). Application au réseau contrôlant l'adhésion entre cellules endothéliales.
  • 17:00-17:30 Grégory Batt (INRIA, Grenoble) : Validation of qualitative models of genetic regulatory networks by model checking: Analysis of the nutritional stress response in Escherichia coli.
  • 17:30-18:00 Arnaud Meyroneinc (CPT, Marseille) : Discrete-time piecewise-affine models of genetic regulatory networks
  • 18:00-18:30 Elisabeth Pécou (LBMG - Université du Chili) : Un modèle de la dynamique d'un réseau mixte : homéostasie du cuivre chez E. Hirae.

• Session: "How to model the cellular dynamics?".
  • 10:00-10:45 Thomas Lecuit (LGPD, Marseille) : Mouches et mousses : quels points communs ?
  • 10:45-11:30 François Graner (UJF Grenoble): Mousse de savon et épithélium: aller plus loin que l'analogie.
  • 11:30-12:15 Michel Kerszberg (UMR 7138 Jussieu Paris): Modélisation informatique des processus en morphogenèse biologique.
  • Lunch
  • 14:15-15:00 Stephane Noselli (UMR 6543 Nice) : Genomic and quantitative analysis of sealing epithelia in Drosophila.

• Thematic working groups: from regulatory structures to dynamical properties, inferring regulatory networks from data, integrated modelling of metabolic and genetic networks...

Friday, May 13th

• Thematic working groups
• Conclusions